Complex Trait Community
8th Annual Meeting

Manchester, 2nd-5th May 2009



Note that the details of thuis programe may change.


Saturday, 2nd May 2009

14:00 Registration opens

16:00 – 18:00 First Session: Status of the Collaborative Cross
Chair Fernando Pardo-Manuel de Villena

16:00 - 16:30 The Mouse Diversity Outcross Population (Karen L Svenson)

16:30 – 17:00 Relocation of the US Collaborative Cross Breeding Program (Fernando Pardo-Manuel de Villena and David Threadgill)

17:00 – 17:30 News from Israel (Fuad Iraqi)

17:30 – 18:00 News from Australia (Grant Morahan)

18:00 Reception (Details TBA)


Sunday, 3rd May 2009

9:00 – 10:00 Keynote Lecture
Diethard Tautz (Max-Planck Institute for Evolutionary Biology, Plön, Germany)
"Genetic basis of adaptation in wild mouse populations"

Contributed papers:

10:00 – 10:20 Adaptive evolution of interferon gamma in Glire lineage and evidence for a recent selective sweep in Mus. m. domesticus (Pasteur)

10:20 – 10:40 Combined QTL research and expression analysis to dissect the early susceptibility of MBT/Pas mice to Rift Valley fever (Tânia Zaverucha do Valle)


Coffee Break


11:00 – 11:20 Genetic background greatly influences the host defence to influenza A infections (Klaus Schughart)

11:20 – 11:40 A new model for identifying host genetic contributions to viral disease. The Collaborative Cross and Influenza A Virus (Marty Ferris)

11:40 – 13:00 Short Poster Presentations

13:00 – 16:00 Lunch, Poster Session, Coffee

16:00 - 16:20 Detecting and characterizing genetic background dependent imprinting effects (Jason Wolf)

16:20 – 16:40 Chromosome Substitution Strains and Gene Expression Analysis Identifies Grb10 as a Candidate Imprinted Modifier of Neurofibromatosis (Karlyne M. Reilly)

16:40 – 17:00 Direct Linkage of Mitochondrial Genome Variation to Risk Factors for Type 2 Diabetes in Conplastic Strains (M. Pravenec)

17:00 – 17:20 A balance of Ttc9c isoforms controls the Diasporin inherited metastasis susceptibility pathway (K. Hunter)

17:20 – 17:40 Gsta4 is a candidate gene for the skin tumor promotion susceptibility locus Psl1.2 (Joe Angel)

17:40 – 18:00 (Summing up)


Monday, 4th May 2009

9:00 – 10:00 Keynote Lecture:
Monika Stoll (Leibnitz-Institut für Arterioskleroseforschung, Münster, Germany)
"Evolutionary Genetics and Complex Diseases"

10:00 – 10:20 Genetic evaluation of populations of wild and outbred mouse reveals near single gene resolution for whole genome association studies (Yalcin)

10:20 – 10:40 A Cross-species Neurogenomics Approach to Anxiety (Donner)


10:40– 11:10 Coffee Break


11:10 – 11:30 A multiparent advanced intercross of the plant Arabidopsis thaliana: (1) Fine-mapping QTLs. (Paula Kover)

11:30 – 11:50 A multiparent advanced intercross of the plant Arabidopsis thaliana: (2) Using Resequencing data to identify quantitative trait nucleotides (Richard Mott)

11:50 – 13:00 Poster Session presentations


13:00 – 16:00 Lunch, Poster sessions and Coffee


16:00 – 16:20 Chromosome Y variants from different mouse inbred strains modulate the organizational effects of perinatal testosterone on the responsiveness of hearts to testosterone later during adult life (C. F. Deschepper)

16:20 – 16:40 Resistance to plague in Mus spretus mice is under complex genetic control with sex-specific QTLs and epistatic interactions (Charlène Blanchet)

16:40 -17:00 Mapping Additive, Dominance, and Genomic Imprinting Quantitative Trait Loci for Dietary Obesity in the LG,SM F16 generation Advanced Intercross Line of Mice (James Cheverud)

17:00 – 17:20 Heritability of phenotypic traits related to disease resistance in the Collaborative Cross mouse population (Fuad Iraqi)

17:20 – 17:40 Mapping Bone Mineral Density QTL in the Collaborative Cross (Ackert-Bichnell)

17:40 – 18:00 The plasticity of the epigenome: Genomic imprinting effects on complex traits can be modified by maternal environment (Reinmar Hager)


Tuesday, 5th May 2009

9:00 – 10:00 Keynote Lecture
Paul Schofield (University of Cambridge)
"Mouse databases and Minimal Information Standards"

10:00 – 10:30 Genetic Structure and QTL Analysis in the Collaborative Cross And Extracting and Validating Gene-Phenotype Association Networks Using the Ontological Discovery Environment (Chesler)

10:30 – 10:50 A Hidden Markov Model Approach to Infer Haplotype Origin subject to Breeding Constraints (Wang)


10:50 – 11:10 Coffee break


11:10 - 11:30 Critical reasoning on causality: extreme accuracy and large sample sizes will be needed in systems genetics (Yang Li )

11:30 – 13:00 Open Business Meeting


13:00 – 14:00 Lunch Break


14:00 – 15:00 Keynote Lecture
Andy Brass (University of Manchester)
"Pathway analysis of complex genome sequence expression data"

15:00 – 15:20 Identifying copy number variants in mice using the Mouse Diversity Array (Palmer)

15:20 – 15:40 A customized and versatile high-density genotyping array for the mouse (Yang)


18:00 Bar opens


Farewell dinner (details TBA)


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